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Search Results for " monocarboxylate transporter "

12

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T5208	BAY-8002 BAY8002,BAY 8002	Monocarboxylate transporter	Membrane transporter/Ion channel
	BAY-8002 是一种可口服的单羧酸转运蛋白第 1 亚型 MCT1 选择性抑制剂，在表达 MCT1 的 DLD-1 细胞中，IC50值为 85 nM，具有抗肿瘤活性。
T3210	AZD3965 AZD 3965,AZD-3965	Monocarboxylate transporter	Membrane transporter/Ion channel
	AZD3965 (AZD-3965) 是单羧酸转运蛋白 1 (MCT1) 的选择性抑制剂，Ki 值为1.6 nM，比 MCT2的选择性高6倍。
T1768	7ACC2	Mitochondrial Metabolism; Monocarboxylate transporter	Membrane transporter/Ion channel; Metabolism
	7ACC2 是单羧酸盐转运蛋白抑制剂，IC50为 11 nM。它还是线粒体丙酮酸转运的有效抑制剂，可抑制乳酸涌入，通过抑制乳酸通量来发挥抗癌作用。
T14316	AR-C155858	Monocarboxylate transporter	Membrane transporter/Ion channel
	AR-C155858 是单羧酸转运蛋白 MCT1 和 MCT2 的抑制剂，Ki 分别为2.3和 10 nM。
T7460	α-Cyano-4-hydroxycinnamic acid α-Cyano-4-hydroxycinnamic acid(α-CHCA),2-氰基-4-羟基	Monocarboxylate transporter	Membrane transporter/Ion channel
	α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) 是非竞争性单羧酸盐转运蛋白 (MCTs) 抑制剂，可抑制线粒体丙酮酸转运蛋白，Ki 值为 6.3 μM。它可作为基质辅助激光解吸电离-飞行时间质谱 (MALDI-TOF) 分析的基质，可以促进肽离子化。
T5845	7ACC1 DEAC,香豆素D1421,Coumarin D 1421,7-(二乙胺基）-2-氧代-2-苯并吡喃-3-羧酸,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421	Monocarboxylate transporter	Membrane transporter/Ion channel
	7ACC1 (D 142) 抑制表达MCT1和MCT4肿瘤细胞的乳酸涌入，能选择性干扰肿瘤微环境乳酸通量。
T67727	MCT1-IN-3	Monocarboxylate transporter	Membrane transporter/Ion channel
	MCT1-IN-3是一种单羧酸转运蛋白1 (MCT1)抑制剂。溶质载体(SLC)单羧酸转运蛋白1 (MCT1);SLC16A1)是治疗癌症的一个有希望的靶点。MCT1-IN-3(化合物24)对MCT1转运抑制作用强，IC50值为81.0 nM。MCT1-IN-3对多药转运体ABCB1也有明显的抑制作用。
T26221	MCT1-IN-2 SR13800,SR-13800,SR 13800
	SR13800 is a monocarboxylate transporter 1 (MCT1) inhibitor with cell-permeable.
T37822	AR-C 141990 hydrochloride
	Monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.
T37824	MCT4-IN-1 MCT4-IN-1
	MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MCT4-IN-1 has the potential for MCT4 transporter inhibition research[1].
T70903	KRH102053
	KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells.
T68511	KRH102140
	KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube format...

化合物

Cat.No: T5208

Synonym: BAY8002,BAY 8002

Target: Monocarboxylate transporter

Cat.No: T3210

Synonym: AZD 3965,AZD-3965

Target: Monocarboxylate transporter

Cat.No: T1768

Target: Mitochondrial Metabolism, Monocarboxylate transporter

Cat.No: T14316

Target: Monocarboxylate transporter

α-Cyano-4-hydroxycinnamic acid

Cat.No: T7460

Synonym: α-Cyano-4-hydroxycinnamic acid(α-CHCA),2-氰基-4-羟基

Target: Monocarboxylate transporter

Cat.No: T5845

Synonym: DEAC,香豆素D1421,Coumarin D 1421,7-(二乙胺基）-2-氧代-2-苯并吡喃-3-羧酸,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421

Target: Monocarboxylate transporter

Cat.No: T67727

Target: Monocarboxylate transporter

Cat.No: T26221

Synonym: SR13800,SR-13800,SR 13800

AR-C 141990 hydrochloride

Cat.No: T37822

Cat.No: T37824

Synonym: MCT4-IN-1

Cat.No: T70903

Cat.No: T68511

Cat. No.	Product Name	Target	Signaling Pathways
TN2252	Syrosingopine	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Syrosingopine 是 MCT1和 MCT4双重抑制剂，对 MCT4 的效力高 60 倍，可防止乳酸和 H+ 流出。它是可口服抗高血压药物，联合二甲双胍具有研究癌症疾病的潜力。

天然产物

Cat.No: TN2252

Target: Dopamine Receptor

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